Predicting steroidogenic toxicity with assay data

Description

A set of in vitro assays are used to quantify the risk of reproductive toxicity via the disruption of steroidogenic pathways.

Details

H295R cells were used to measure the effect with two sets of assay results. The first includes a set of protein measurements on: cytochrome P450 enzymes ("cyp"s), STAR, and 3BHSD2. The second include hormone measurements for DHEA, progesterone, testosterone, and cortisol.

Columns:

• class: factor (levels: 'toxic' and 'nontoxic')

• cyp_11a1: numeric

• cyp_11b1: numeric

• cyp_11b2: numeric

• cyp_17a1: numeric

• cyp_19a1: numeric

• cyp_21a1: numeric

• hsd3b2: numeric

• star: numeric

• progesterone: numeric

• testosterone: numeric

• dhea: numeric

• cortisol: numeric

Value

A tibble with columns

• class: factor(levels: toxic and nontoxic)

• cyp_11a1: numeric

• cyp_11b1: numeric

• cyp_11b2: numeric

• cyp_17a1: numeric

• cyp_19a1: numeric

• cyp_21a1: numeric

• hsd3b2: numeric

• star: numeric

• progesterone: numeric

• testosterone: numeric

• dhea: numeric

• cortisol: numeric

Source

Maglich, J. M., Kuhn, M., Chapin, R. E., & Pletcher, M. T. (2014). More than just hormones: H295R cells as predictors of reproductive toxicity. Reproductive Toxicology, 45, 77-86.

Examples

data(steroidogenic_toxicity)
str(steroidogenic_toxicity)