Overdose | R Documentation |

## Overdose of Amitriptyline

### Description

Data on overdoses of the drug amitriptyline.
Amitriptyline is a drug prescribed by physicians as an antidepressant. However, there are also
conjectured side effects that seem to be related to the use of the drug: irregular heart beat,
abnormal blood pressure and irregular waves on the electrocardiogram (ECG).
This dataset (originally from Rudorfer, 1982) gives data on 17 patients admitted to hospital after an overdose
of amitriptyline.
The two response variables are: `TCAD`

and `AMI`

. The other variables are predictors.

### Usage

```
data("Overdose")
```

### Format

A data frame with 17 observations on the following 7 variables.

`TCAD`

total TCAD plasma level, a numeric vector

`AMI`

amount of amitriptyline present in the TCAD plasma level, a numeric vector

`Gender`

a factor with levels

`Male`

`Female`

`amount`

amount of drug taken at time of overdose, a numeric vector

`BP`

diastolic blood pressure, a numeric vector

`ECG_PR`

ECG PR wave measurement, a numeric vector

`ECG_QRS`

ECG QRS wave measurement, a numeric vector

### Source

Johnson & Wichern (2005), *Applied Multivariate Statistical Analysis*,
Exercise 7.25, p. 426.

### References

Rudorfer, M. V. Cardiovascular changes and plasma drug levels after amitriptyline overdose. (1982).
*J. Toxicology - Clinical Toxicology*. **19**(1),67-78.
doi:10.3109/15563658208990367, PMID: 7154142.

Clay Ford, "Getting started with Multivariate Multiple Regression", https://library.virginia.edu/data/articles/getting-started-with-multivariate-multiple-regression.

ECG measurements:

### Examples

```
data(Overdose)
str(Overdose)
pairs(Overdose)
over.mlm <- lm(cbind(TCAD, AMI) ~ Gender + amount + BP + ECG_PR + ECG_QRS, data = Overdose)
coef(over.mlm)
# check for outliers
cqplot(over.mlm)
# HE plot shows that relations of responses to predictors are essentially one-dimensional
heplot(over.mlm)
# canonical correlation analysis
if(require(candisc)) {
cancor(cbind(TCAD, AMI) ~ as.numeric(Gender) + amount + BP + ECG_PR + ECG_QRS, data = Overdose)
}
```