Pharmacokinetics of Indomethacin

Description

The Indometh data frame has 66 rows and 3 columns of data on the pharmacokinetics of indometacin (or, older spelling, ‘indomethacin’).

Usage

Indometh

Format

An object of class c("nfnGroupedData", "nfGroupedData", "groupedData", "data.frame") containing the following columns:

Subject

an ordered factor with containing the subject codes. The ordering is according to increasing maximum response.

time

a numeric vector of times at which blood samples were drawn (hr).

conc

a numeric vector of plasma concentrations of indometacin (mcg/ml).

Details

Each of the six subjects were given an intravenous injection of indometacin.

This dataset was originally part of package nlme, and that has methods (including for [, as.data.frame, plot and print) for its grouped-data classes.

Source

Kwan, Breault, Umbenhauer, McMahon and Duggan (1976) Kinetics of Indomethacin absorption, elimination, and enterohepatic circulation in man. Journal of Pharmacokinetics and Biopharmaceutics 4, 255–280.

Davidian, M. and Giltinan, D. M. (1995) Nonlinear Models for Repeated Measurement Data, Chapman & Hall (section 5.2.4, p. 129)

Pinheiro, J. C. and Bates, D. M. (2000) Mixed-effects Models in S and S-PLUS, Springer.

See Also

SSbiexp for models fitted to this dataset.