ashkenazi

Description

This is a random subset of data from the Struewing et al. (1997) study of Ashkenazi jews and breast cancer. The subset consists of pairs of first-degree female relatives who are also first degree relatives of a proband.

Usage

data("ashkenazi")

Format

A data frame with 3920 observations on the following 4 variables.

famID

family ID indicator

brcancer

1 if subject had breast cancer, 0 if not

age

Age at onset of breast cancer, or current age if no breast cancer

mutant

1 if first degree relative proband was a BRCA mutation carrier, 0 if not

References

Moore DF, Chatterjee N, Pee D, and Gail MH (2001) Pseudo-likelihood estimates of the cumulative risk of an autosomal dominant disease from a kin-cohort study. Genetic Epidemiology 20, 210-227.)

Struewing JP, Hartge P, Wacholder S, Baker SM, Berlin M, McAdams M, Timmerman MM, Brody LC, and Tucker MA (1997) The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among ashkenazi jews. New England Journal of Medicine 336, 1401-1408.)

Examples

data(ashkenazi)