AmyloidR Documentation

Amyloid-beta and Cognitive Impairment


Amyloid-beta and cognitive impairment for a sample of Catholic priests


A data frame with 57 observations on the following 2 variables.


mAD=Alzheimer's, MCI=mild impairment, NCI=no impairment


Amount of Abeta from the posterior cingulate cortex (pmol/g tissue)


Amyloid-beta (Abeta) is a protein fragment that has been linked to Alzheimer's disease. Autopsies from a sample of Catholic priests included measurements of Abeta (pmol/g tissue from the posterior cingulate cortex) from three groups: subjects who had exhibited no cognitive impairment before death, subjects who had exhibited mild cognitive impairment, and subjects who had mild to moderate Alzheimer's disease.


Violetta N. Pivtoraiko, Eric E. Abrahamson, Sue E. Leurgans, Steven T. DeKosky, Elliott J. Mufson,, Milos D. Ikonomovic (2015) Cortical pyroglutamate amyloid-beta levels and cognitive decline in Alzheimer's disease. Neurobiology of Aging (36) 12-19. Data are read from Figure 1, panel d.