LanzaR Documentation

Prevention of Gastointestinal Damages


Data from four randomised clinical trials on the prevention of gastointestinal damages by Misoprostol reported by Lanza et al. (1987, 1988a,b, 1989).




A data frame with 198 observations on the following 3 variables.


a factor with levels I, II, III, and IV describing the study number.


a factor with levels Misoprostol Placebo


an ordered factor with levels 1 < 2 < 3 < 4 < 5 describing an ordered response variable.


The response variable is defined by the number of haemorrhages or erosions.


F. L. Lanza (1987), A double-blind study of prophylactic effect of misoprostol on lesions of gastric and duodenal mucosa induced by oral administration of tolmetin in healthy subjects. British Journal of Clinical Practice, May suppl, 91–101.

F. L. Lanza, R. L. Aspinall, E. A. Swabb, R. E. Davis, M. F. Rack, A. Rubin (1988a), Double-blind, placebo-controlled endoscopic comparison of the mucosal protective effects of misoprostol versus cimetidine on tolmetin-induced mucosal injury to the stomach and duodenum. Gastroenterology, 95(2), 289–294.

F. L. Lanza, K. Peace, L. Gustitus, M. F. Rack, B. Dickson (1988b), A blinded endoscopic comparative study of misoprostol versus sucralfate and placebo in the prevention of aspirin-induced gastric and duodenal ulceration. American Journal of Gastroenterology, 83(2), 143–146.

F. L. Lanza, D. Fakouhi, A. Rubin, R. E. Davis, M. F. Rack, C. Nissen, S. Geis (1989), A double-blind placebo-controlled comparison of the efficacy and safety of 50, 100, and 200 micrograms of misoprostol QID in the prevention of ibuprofen-induced gastric and duodenal mucosal lesions and symptoms. American Journal of Gastroenterology, 84(6), 633–636.


  data("Lanza", package = "HSAUR")
  layout(matrix(1:4, nrow = 2))
  pl <- tapply(1:nrow(Lanza), Lanza$study, function(indx)
                 main = "", shade = TRUE))